Assad's forces carried out a blast, which hit the Muhafaza Sakaniya neighborhood in a western district of Aleppo. 12 Muslims were killed in the Aleppo attack and dozens were wounded.
Last Tuesday, Assad killed 87 Muslims in twin blasts at Aleppo University.
Meanwhile, Assad's airstrikes have continued in several suburbs of the Syrian capital. The heaviest fighting was reported in Daraya.
Activists said at least 11 civilian Muslims were killed, including four children, from one strike and others are still trapped under the rubble.
Also on Friday, fighting between Syrian Mujahideen and Assad's gangs flared in a Palestinian refugee camp in Damascus, killing 12 people and wounding at least 20 others.
Children were among Assad's victims.
The Palestinian camp called Yarmouk has been the scene of heavy clashes between Mujahideen and Alawite Assad's gangs since mid-December, when Mujahideen fighters moved into the camp during an attempt to storm the capital.
About half of Yarmouk's 150,000 residents have fled since fighting erupted.